Cancer of Unknown Primary Foundation Meeting 2019
The ‘unknown’ is, for the most part, capable of being ‘known’ yet CUP remains a significant challenge for clinicians and patients across the world. In the UK, CUP is the 5th highest cause of cancer mortality. Chaired by Dr F Anthony Greco, the focus of this meeting will be on international CUP research and clinical management themes in the era of precision medicine. This conference is organised by the CUP Foundation supported by NCRI, with administrative support from SBK Healthcare.
This event is only conference dedicated exclusively to CUP in the world. It will enable attendees to share experiences and ideas with members of the national and international CUP community. As a dedicated forum, it offers the unique opportunity to hear leading experts and practitioners in the field report on emerging CUP research and clinical developments. The day will include a ‘prophecy discussion’ about how CUP research might unfold in the future. (CPD approval credits will be sought).
We are now on the cusp of a new dawn for CUP patients where the focus is on finding the molecular primary or finding the molecular target. In the previous conferences (CUP 2009; CUP 2012; CUP 2015) research and management approaches had a strong bias towards identifying the anatomical site of the primary to target with chemotherapy – often with considerable guesswork and standardisation. The objective of this event is to recognise and explore current research and management themes in relation to:
- Diagnosis of the cancer type in CUP (not the anatomical primary) – critical to the optimal therapy for each patient
- The use of Next Generation Sequencing (NGS) to identify actionable genetic mutations for targeting with appropriate drugs
- How Immunotherapy might be used in conjunction with NGS to predict a favourable response to immune checkpoint blockers
The CUP Foundation are pleased to invite clinicians, researchers and others with an interest in CUP to be part of this conference.
If you wish to offer a poster to the conference please submit an abstract on one side of A4 paper to Director@cupfoundjo.org that shows clearly what you wish to present, with key findings and the abstract’s relevance to one or more of the following: CUP research/ clinical management/ patient outcomes including QOL/ health economics . A prize of £100 will be awarded after the event to the principal author of the poster judged to be best by the conference committee. At least one author must register and attend the conference with the poster. Abstracts should be submitted by 30 Mar – notification by 15 Apr.
Please email Nichola.firstname.lastname@example.org for further details
You can see more about the Cancer of the Unknown Primary Foundation’s previous conferences and seminars by visiting https://cupfoundjo.org/research/conferences-archive
View further details and find out how to buy the documentation for Systematic Anti-Cancer Therapy (SACT) Service Delivery
The outline timings for the day are 9.00 - 5.30, with Registration at 8.30. There will be drinks at 5.30 hours and the award of the poster prize. Refreshments, lunch and programme materials are included in the delegate fee. Visit https://cupfoundjo.org/conference for further details.
|8.30||Registration and coffee|
Session 1 - Current optimal diagnostics for CUP tissue of origin. Chair: Tony Greco
|9.25||State of the art immunohistochemistry for the diagnosis of tissue of origin: Royal College of Pathologists standard. |
Speaker: John Schofield.
|9.40||Evolving morphomolecular pathology in the diagnosis of the tissue of origin. |
Speaker: Karin Oien.
|9.55||The usefulness and potential of the epigenic/methylation assay (EPICUP) for tissue of origin diagnosis. |
Speaker: Manel Esteller.
|10.10||Progress, accuracy & limitations of available molecular cancer classifier assays for tissue of origin diagnosis: review of various assays. |
Speaker: Richard Tothill.
|10.30||Comprehensive genomic profiling of CUP: therapeutic implications. |
Speaker: Prasanth Reddy.
|11.30||Panel discussion with audience questions. Therapeutic importance of tissue of origin diagnosis and other biomarkers in CUP.|
Panelists: Doctors Greco, Schofield, Oien, Tothill, Esteller, Wasan, Reddy, Cook
Session 2 - Clinical and translational trials. Chair: Harpreet Wasan
|11.55||Update on UK studies including CUP-One, 100k Genomes Project and CUP GeCIP. |
Speaker: Harpreet Wasan.
|12.10||The SUPER Australian study; selected update and perceptions of CUP by medical oncologists, a national survey. |
Speaker: Penny Schofield.
|12.25||Japanese phase II study of empiric chemotherapy versus site directed therapy based on a molecular cancer classifier assay and the Phase III GEPCAP104 study; global view/background of CUPISCO study: importance and limitations regarding CUP management. |
Speaker: Alwin Krämer.
|12.45||CUPISCO study; UK specifics & commentary. |
Speaker: Kai-Keen Shiu.
|2.00||US studies: Sarah Cannon retrospective CUP subsets, Phase II molecular classifier based site specific therapy, immune checkpoint blockers and MyPathway, NCI Match, ASCO Tapur. |
Speaker: Tony Greco.
|2.25||Panel discussion with audience questions.|
Panelists: Doctors Wasan, Greco, Schofield, Kramer, Shiu, Cook, Reddy
Session 3 - Optimal clinical management and focus on the future. Chair Tony Greco
|2.45||Integration of a molecular cancer classifier and comprehensive molecular profiling in selected patients. |
Speaker: Tony Greco.
|3.10||Review of evolving technologies including liquid biopsies and circulating tumor cells. |
Speaker: Natalie Cook.
|4.00||Whole genome sequencing and immune profiling. |
Speaker: Richard Tothill.
|4.15||The Cancer genome atlas (TCGA) and the search for a CUP genetic/epigenetic signature. |
Speaker: Manel Esteller.
|4.30||Debate 1. CUP is a single type of cancer with unique biology and response to therapies?|
For: Alwin Krämer. Against: Tony Greco
|4.45||Debate 2. CUP is a clinical/pathological syndrome of many specific cancer types with occult primaries but predictable responses to therapies?|
For: Tony Greco. Against: Alwin Krämer
|5.00||Debate 3. Comprehensive molecular profiling should be the preferred test rather than a molecular cancer classifier assay?|
For: Prasanth Reddy. Against: Natalie Cook
|5.30||Discussion: optimal management of CUP in 2019 and future research priorities.|
All speakers with audience participation
|6.00||Drinks and poster prize award|
The full agenda and speaker details will be available during the next few months. The confirmed speakers are shown on the CUP Foundation website https://cupfoundjo.org/conference/speakers
This pricing structure applies across this conference and related events
- As a CUP Foundation event there is no VAT on these prices
- £150 per place
- No charge - CUP patients and carers
Do you really want to attend an event, but can’t see funding being available? SBK Healthcare have put together a page of cost saving tips, travel advice and useful ideas to help you to build your business case. Click here to view the justify your attendance document.
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The Royal College of Physicians
11 St Andrews Place, London, NW1 4LE, Tel: 020 3075 1200 or 020 3075 1363.
The Royal College of Physicians is located in central London at 11 St Andrews Place, London NW1 4LE . The College is easily accessible by public transport and convenient for those travelling by Eurostar from the Continent.
Travel is not included in the conference fee. It is the responsibility of each delegate to make their way to the conference venue in adequate time. The conference organisers are not liable for any delays or non-attendance resulting from delayed or suspended transportation.
A full refund of fees will be made only for cancellations received in writing 28 days before the date of the event (less £90 administration charge). Notice of cancellation must be received in writing and submitted by contacting us here. Should you need to cancel your registration after this date, the registration fee remains payable in its entirety although a substitution will be accepted and conference documentation will be provided. You are still entitled to conference documentation in the event of cancellation.
Substitutions & Name Changes
Substitutions for delegates unable to attend after registering are acceptable at any time. To inform us of a name change, please contact us here. It may be necessary for reasons beyond the control of the conference organisers to alter the venue, content, speakers or the timing of the programme. We will endeavour to keep you abreast of such changes but any unavoidable change to the conference format will not constitute a reason to refund the conference fee. Should the event be postponed, we will endeavour to reschedule the event. If, for reasons beyond the control of the conference organiser, the event is cancelled, a full refund will be made. We do not accept any liability for any incurred costs resulting from a postponement or cancellation.
Certification of Attendance
A certificate for Continuing Professional Development will be given to each participant who completes the course, as a record of your continuing professional training and development.
Registration fees are payable in advance. The fee includes documentation, refreshments and lunch, it does not include travel costs or accommodation. If your fee has not been received prior to the event, delegates without proof of payment will be asked for either a credit card guarantee on the day or to sign a proof of attendance form.
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If you are unable to attend or would like to pick up an additional set of documentation on the day, the event documentation is available for purchase at £89 per set.